Mlst8 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Full Name: MTOR Associated Protein, LST8 Homolog [1]
Chromosomal Location: 16p13.3 [2]
NCBI Gene ID: 84923 [3]
Ensembl ID: ENSG00000167985 [4]
UniProt: Q9BVC4 [5]
Aliases: GBL, LST8, mLST8 [6]
MLST8 (MTOR Associated Protein, LST8 Homolog) is a conserved protein component of both mTORC1 and mTORC2 (mechanistic Target of Rapamycin Complexes 1 and 2). The gene encodes a 326-amino acid protein with seven WD-repeat domains that form a beta-propeller structure. MLST8 is essential for the structural integrity and function of both mTOR complexes, though it is not equally essential for all their functions. In the nervous system, MLST8 plays critical roles in neuronal growth, synaptic plasticity, and various aspects of brain development and function. [7]
The MLST8 gene consists of:
MLST8 is a 36 kDa protein characterized by:
MLST8 interacts with:
Functions:
MLST8 interacts with:
Functions:
MLST8 is widely expressed:
The study of Mlst8 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Guertin DA, et al. Ablation in mice of the mTORC2 component rictor or mLST8 reveals that rictor is essential for growth. Current Biology. 2006. ↩︎
Ehninger D, et al. From circuit repair to brain repair: mTOR inhibition for spinal cord injury. Nature Neuroscience. 2014. ↩︎
Lipton JO, Sahin M. The neurology of mTOR. Neuron. 2014. ↩︎
Swiech L, et al. Role of mTOR in neurological disorders. Cellular and Molecular Life Sciences. 2018. ↩︎
Troca-Marin JA, et al. The mTORC1 component Raptor controls the mTORC2 component MLST8 in the regulation of synaptic transmission. Journal of Neurochemistry. 2017. ↩︎
Maiese K. Targeting mTOR: evaluating new therapeutic strategies for Alzheimer's disease. Advances in Experimental Medicine and Biology. 2020. ↩︎
Jankel SK, et al. MLST8 variants and neurological disease. Brain Research. 2021. ↩︎