Map3K5 — Mitogen Activated Protein Kinase Kinase Kinase 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| MAP3K5 (ASK1) | |
|---|---|
| Gene Symbol | MAP3K5 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 5 |
| Chromosome | 6q26 |
| NCBI Gene ID | 4217 |
| OMIM | 602476 |
| Ensembl ID | ENSG00000197442 |
| UniProt ID | Q9UHD6 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, ALS, Stroke |
This page provides comprehensive information about the MAP3K5 gene and its role in neurodegenerative diseases. The gene encodes a protein involved in various molecular pathways relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
MAP3K5 encodes ASK1 (Apoptosis Signal-regulating Kinase 1), a MAP3K that activates JNK and p38 MAPK pathways in response to stress. ASK1 is a critical mediator of:
ASK1 activates:
ASK1 is kept inactive by thioredoxin and 14-3-3 proteins under normal conditions.
ASK1 is expressed in most tissues:
The study of Map3K5 — Mitogen Activated Protein Kinase Kinase Kinase 5 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This page was created to expand the NeuroWiki gene database for neurodegenerative disease research.