Maob Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
MAOB (Monoamine Oxidase B) is a mitochondrial enzyme encoded by the MAOB gene on chromosome Xp11.23[1]. It primarily metabolizes phenylethylamine and benzylamine, and plays a critical role in dopamine catabolism in the brain[2]. MAOB is predominantly expressed in platelets and in the mitochondrial outer membrane of serotonergic and dopaminergic neurons.
| MAOB - Monoamine Oxidase B | |
|---|---|
| Gene Symbol | MAOB |
| Full Name | Monoamine Oxidase B |
| Chromosomal Location | Xp11.23 |
| NCBI Gene ID | 4129 |
| OMIM ID | 309860 |
| Ensembl ID | ENSG00000105707 |
| UniProt ID | [P50395](https://www.uniprot.org/uniprot/P50395) |
| Protein Family | Monoamine oxidase family |
| Subcellular Location | Mitochondrial outer membrane |
MAOB has distinct substrate specificity:
| Drug | Type | Status | Indication |
|---|---|---|---|
| Selegiline | Irreversible | Approved (FDA) | Parkinson's disease (adjunct) |
| Rasagiline | Irreversible | Approved (FDA) | Parkinson's disease |
| Safinamide | Reversible | Approved | Parkinson's disease |
| Ladostigil | Irreversible | Research | AD/PD |
The study of Maob Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Single-cell RNA sequencing data from the Allen Brain Atlas shows MAOB expression:
Key observations:
External Resources:
Mandel SA, Amit T, Kalfon L, et al. Targeting multiple neurodegenerative disease etiologies through multi-modal neuroprotective compounds. Exp Neurol. Targeting multiple neurodegenerative disease etiologies through multi-modal neuroprotective compounds. 2020. ↩︎ ↩︎
Bortolato M, Chen K, Shih JC. Monoamine oxidase B deficiency. J Neural Transm. Monoamine oxidase B deficiency. 2021. ↩︎