Mag Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Mag Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
MAG (Myelin-Associated Glycoprotein) is a critical component of the myelin sheath in the central and peripheral nervous systems. It plays essential roles in maintaining myelin integrity, axonal-glial interactions, and has been implicated in various neurological disorders.
| Property | Value |
|---|---|
| Gene Symbol | MAG |
| Full Name | Myelin-Associated Glycoprotein |
| Chromosomal Location | 19q13.12 |
| NCBI Gene ID | 4099 |
| OMIM | 159460 |
| Ensembl ID | ENSG00000141670 |
| UniProt | P20916 |
| Associated Diseases | Multiple Sclerosis, Hereditary Spastic Paraplegia, ALS |
MAG is a member of the siglec family with important functions in the nervous system:
MAG is expressed in:
Title: Myelin-associated glycoprotein: a member of the siglec family
Authors: Schachner M, Bartsch U
Journal: Journal of Neurocytology
Year: 2000
[DOI:10.1023/A:1007049613732](https://doi.org/10.1023/A:1007049613732)
Title: MAG defines the inhibitory component of CNS myelin
Authors: McKerracher L, et al.
Journal: Neuron
Year: 1994
[DOI:10.1016/0896-6273(94](https://doi.org/10.1016/0896-6273(94))90219-4
Mag Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Mag Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.