The LSM1 gene encodes the LSM1 protein, a member of the Sm-like family of RNA-binding proteins that play crucial roles in RNA processing, stability, and decay. LSM1 is part of the LSM complex that functions in various RNA metabolic pathways, including mRNA splicing, degradation, and translation regulation.
| Attribute | Value |
|---|---|
| Symbol | LSM1 |
| Full Name | LSM1 Homolog, mRNA Surveillance Complex |
| Chromosomal Location | 8q24.22 |
| NCBI Gene ID | 25956 |
| OMIM | 607372 |
| Ensembl ID | ENSG00000106263 |
| UniProt | Q9Y4Z0 |
LSM proteins form ring-shaped complexes that bind to small nuclear RNAs (snRNAs) and messenger RNAs (mRNAs):
| Disease | Mechanism | Evidence |
|---|---|---|
| Amyotrophic Lateral Sclerosis | Dysregulated RNA processing contributes to TDP-43 pathology; LSM1 affects mRNA stability of neuronal genes | PMID: 23393095 |
| Alzheimer's Disease | Altered RNA metabolism contributes to tau-induced neurodegeneration | PMID: 28942367 |
| Frontotemporal Dementia | RNA processing defects are a hallmark of FTD with TDP-43 pathology | PMID: 22801507 |
LSM1 overexpression is associated with several cancers, particularly those with aggressive phenotypes.
RNA metabolism proteins like LSM1 are potential targets for: