Lrp5 — Low Density Lipoprotein Receptor Related Protein 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| LRP5 Gene | |
|---|---|
| Gene Symbol | LRP5 |
| Full Name | Low-Density Lipoprotein Receptor-Related Protein 5 |
| Chromosomal Location | 11q13.2 |
| NCBI Gene ID | 4041 |
| OMIM ID | 603506 |
| Ensembl ID | ENSG00000162337 |
| UniProt ID | O75173 |
| Protein Name | Low-density lipoprotein receptor-related protein 5 |
| Aliases | LRP-5, LRP7 |
| Associated Diseases | Alzheimer's Disease, Osteoporosis-Pseudoglioma Syndrome, Familial Exudative Vitreoretinopathy |
LRP5 (Low-Density Lipoprotein Receptor-Related Protein 5) is a transmembrane receptor that plays critical roles in bone mass regulation, Wnt/β-catenin signaling, and cholesterol metabolism[1][2]. It is a member of the low-density lipoprotein receptor family and functions as a co-receptor for Wnt ligands. LRP5 is widely expressed in bone, retina, and brain, with emerging roles in neurodegenerative diseases.
LRP5 serves as a primary co-receptor in the canonical Wnt/β-catenin signaling pathway:
LRP5 is essential for bone homeostasis:
In the central nervous system:
LRP5 connections to AD include[3][4]:
In PD:
LRP5 is a promising therapeutic target:
Emerging evidence links bone and brain health through LRP5:
The study of Lrp5 — Low Density Lipoprotein Receptor Related Protein 5 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
He X, et al. (2004). LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development. 131(8):1663-1677. PMID:15084453 ↩︎
Gong Y, et al. (2001). LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 107(4):513-523. PMID:11719201 ↩︎
De Ferrari GV, et al. (2007). Common genetic variants within LRP5 are associated with late-onset Alzheimer's disease. Nat Genet. 39(3):355-357. PMID:17277737 ↩︎
Tan MS, et al. (2015). LRP5 polymorphisms and Alzheimer's disease: a meta-analysis. Neuropsychopharmacology. 40(8):1903-1913. PMID:25782801 ↩︎