Lrek Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Lrek Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | LREK |
|---|---|
| Gene Name | LREK |
| Chromosome | 12q12 |
| NCBI Gene ID | 120892 |
| OMIM | 609460 |
| UniProt | Q86X55 |
| Associated Diseases | Parkinson's disease |
Leucine-rich repeat kinase; part of LRRK2 pathway
The LREK gene is implicated in neurodegenerative diseases including:
LREK is expressed in the brain, with highest expression in neurons.
Lrek Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Lrek Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Zimprich A, Biskup S, Leitner P, et al. "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." Neuron. 2004;44(4):601-607. DOI:10.1016/j.neuron.2004.11.005
Paisán-Ruíz C, Jain S, Evans EW, et al. "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease." Neuron. 2004;44(4):595-600. DOI:10.1016/j.neuron.2004.10.023
Cookson MR. "The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease." Nature Reviews Neuroscience. 2010;11(12):791-797. DOI:10.1038/nrn2935
Greggio E, Cookson MR. "Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions." Parkinsonism Relat Disord. 2009;15(4):256-259. DOI:10.1016/j.parkreldis.2008.10.010
West AB, Moore DJ, Biskup S, et al. " Parkinson's disease-associated mutations in LRRK2 link enhanced GTP binding and kinase activity to dopaminergic neuron degeneration." Neuron. 2005;47(4):577-582. DOI:10.1016/j.neuron.2005.08.003
Dächsel JC, Farrer MJ. "LRRK2 and Parkinson's disease: back to the future." Curr Opin Neurol. 2010;23(4):401-407. DOI:10.1097/WCO.0b013e32833b1f5b
Jaleel M, Nichols RJ, Deak M, et al. "LRRK2 phosphorylates moesin at Thr558: identification of a novel pathogenic PINK1 enzymatic cascade downstream of LRRK2." Biochem J. 2007;404(1):179-187. DOI:10.1042/BJ20060757
Singleton AB, Farrer MJ, Bonifati V. "LRRK2 gene in Parkinson disease: confusion of terminology." Lancet Neurol. 2006;5(7):573. DOI:10.1016/S1474-4422(0670483-6