Limk2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-gene
| Gene Symbol | LIMK2 |
| Full Name | LIM Domain Kinase 2 |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 3985 |
| Ensembl ID | ENSG00000182541 |
| UniProt ID | P53671 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Huntington's Disease |
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LIMK2 (LIM Domain Kinase 2) encodes a serine/threonine kinase that, like LIMK1, regulates actin cytoskeleton dynamics through phosphorylation of cofilin family proteins. While LIMK1 and LIMK2 share structural similarities, they have distinct expression patterns and functions. LIMK2 is particularly important in muscle development, brain development, and has been implicated in various neurodegenerative diseases 1.
LIMK2 is a serine/threonine kinase that:
LIMK2 contains:
LIMK2 has multiple isoforms:
LIMK2 involvement in AD:
In PD:
LIMK2 has been specifically implicated in HD:
LIMK2 is expressed in:
LIMK2 represents a potential therapeutic target for neurodegenerative diseases:
The study of Limk2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Huang TY, et al. (2019) - Cofilin in neurodegeneration. 2019. ↩︎
Saitoh M, et al. (2006) - LIMK2 in cell motility. 2006. ↩︎