KCNS3 (Potassium Voltage-Gated Channel Subfamily S Member 3) encodes the Kv9.3 potassium channel subunit, another modulatory subunit expressed predominantly in the nervous and endocrine systems. KCNS3-containing channels contribute to neuronal excitability and hormone secretion.
| Property |
Value |
| Gene Symbol |
KCNS3 |
| Gene Name |
Potassium Voltage-Gated Channel Subfamily S Member 3 |
| Aliases |
KV9.3 |
| Chromosomal Location |
2p24.2 |
| NCBI Gene ID |
3786 |
| OMIM |
603960 |
| UniProt |
Q9BQ92 |
| Ensembl |
ENSG00000124140 |
KCNS3 encodes the Kv9.3 subunit, which modulates voltage-gated potassium channel function:
- Modulatory Function: Does not form functional homomers
- Heteroomeric Assembly: Co-assembles with Kv2.1, Kv2.2, Kv3.x family members
- Altered Kinetics: Generates channels with unique activation/inactivation properties
- Neurons: Throughout CNS and PNS
- Endocrine Cells: Pancreatic beta cells, pituitary, adrenal gland
- Cardiovascular System: Vascular smooth muscle
- Regulates neuronal firing properties
- Modulates synaptic integration
- Affects action potential shape and duration
In endocrine cells, KCNS3 influences:
- Insulin secretion from pancreatic beta cells
- Cortisol release from adrenal cortex
- Pituitary hormone secretion
Contributes to vascular smooth muscle excitability affecting:
- Blood pressure regulation
- Vascular tone
KCNS3 expression is altered in various cancers:
- Some tumors show upregulated KCNS3
- May affect cell proliferation and apoptosis
- Potential role in epilepsy
- Possible involvement in neurodegenerative processes
- May affect neuronal survival under pathological conditions
Altered KCNS3 function may affect beta-cell excitability and insulin secretion
KCNS3 represents a potential drug target:
- Cancer therapy: KCNS3 modulators
- Diabetes treatment: Beta-cell function
- Neurological disorders: Neuronal excitability
KCNS3 encodes a modulatory voltage-gated potassium channel subunit with roles in neuronal excitability, hormone secretion, and vascular function. Altered expression is associated with several disease conditions.
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Stocker & Kerschensteiner, Journal of Physiology (1998)
-
Kerschensteiner et al., European Journal of Neuroscience (2005)
-
Martínez-Mármol et al., Cell Calcium (2017)
-
Bhattacharjee et al., Journal of Neurophysiology (2003)
-
Rashid et al., Journal of Molecular Neuroscience (2014)
-
O'Connell et al., Channels (2010)
-
Weiss et al., Nature Reviews Cancer (2013)
-
Huang & Jan, Cell (2014)