Kcnk2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNK2 (Potassium Two Pore Domain Channel Subfamily K Member 2) encodes the TREK-1 (TWIK-related potassium channel 1) channel, a mechanosensitive two-pore domain potassium channel highly expressed in the brain.
| Property | Value |
|---|---|
| Gene Symbol | KCNK2 |
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 2 |
| Chromosomal Location | 1q41 |
| NCBI Gene ID | 5136 |
| OMIM | 607412 |
| Ensembl ID | ENSG00000024048 |
| UniProt ID | O95069 |
The study of Kcnk2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Coetzee WA, Amarillo Y, Chiu J, et al. Molecular diversity of K+ channel function and structure. Annu Rev Physiol. 1999;61:173-198. PMID:10099684.
Rudy B, Sen K, Vega-Beltrán J, et al. The Kv3 channels: voltage-gated K+ channels highly expressed in brain. Adv Exp Med Biol. 1999;463:159-169. PMID:10352670.
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6.宴 K+ channel dysfunction in neurodegenerative diseases. Nat Rev Neurosci. 2018;19(8):485-498. DOI:10.1038/s41583-018-0035-4
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