Kcnk1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNK1 (Potassium Two Pore Domain Channel Subfamily K Member 1) encodes the TWIK-1 potassium channel, a member of the two-pore domain (K2P) potassium channel family. These channels contribute to the background "leak" conductance that maintains the resting membrane potential.
| Property | | Value |
|----------|-------|
| Gene Symbol | KCNK1 |
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 1 |
| Chromosomal Location | 1q42.12 |
| NCBI Gene ID | 3775 |
| OMIM | 603457 |
| Ensembl ID | ENSG00000135750 |
| UniProt ID | O00180 |
K2P channels contain:
The study of Kcnk1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Wei AD, Gutman GA, Aldrich R, et al. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005;57(4):473-492. PMID:16382103.
Coetzee WA, Amarillo Y, Chiu J, et al. Molecular diversity of K+ channel function and structure. Annu Rev Physiol. 1999;61:173-198. PMID:10099684.
Rudy B, Sen K, Vega-Beltrán J, et al. The Kv3 channels: voltage-gated K+ channels highly expressed in brain. Adv Exp Med Biol. 1999;463:159-169. PMID:10352670.
Hille B. Ion channels of excitable membranes. 3rd ed. Sunderland, MA: Sinauer Associates; 2001.
6.宴 K+ channel dysfunction in neurodegenerative diseases. Nat Rev Neurosci. 2018;19(8):485-498. DOI:10.1038/s41583-018-0035-4
Nerbonne JM, Kass RS. Molecular physiology of cardiac repolarization. Physiol Rev. 2005;85(4):1205-1253. PMID:16183911.
Stocker M. Ca2+-activated K+ channels: molecular determinants and function. Trends Neurosci. 2004;27(6):303-307. PMID:15165735.