Kcnj16 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Kcnj16 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox-gene
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | KCNJ16 - Potassium Inwardly Rectifying Channel Subfamily J Member 16
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! Chromosomal Location
| 17q24.3 |
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! NCBI Gene ID
! OMIM
! Ensembl ID
! UniProt
! Associated Diseases
| Bicarbonate loss, metabolic alkalosis |
|---|
KCNJ16 encodes Kir5.1, an inwardly rectifying potassium channel that often forms heteromers with Kir4.1. It is important for pH sensing and bicarbonate transport in kidney and brain.
Bicarbonate loss, metabolic alkalosis
Expressed in kidney, brain, and salivary glands.
Kcnj16 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Kcnj16 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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[3]: Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci. 2000;1(1):21-30. PMID:11251309
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[8]: Brown BM, et al. Neuronal K+ channels and epilepsy. Novartis Found Symp. 2006;266:74-90. PMID:16720433