Kcnh6 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNH6 (HERG2, ERG2) is a potassium channel expressed predominantly in the gastrointestinal tract. It regulates gastric and intestinal motility. It is distinct from the cardiac HERG channel.
KCNH6 (Potassium Voltage-Gated Channel Subfamily H Member 6) is a gene located on chromosome 17q24 that plays an important role in neurodegenerative disease. Mutations in KCNH6 are associated with Gastrointestinal Disorders, Intestinal Motility. The gene is catalogued as NCBI Gene ID 27151 and OMIM 613391.
The KCNH6 gene encodes a protein involved in key neuronal functions. It is expressed in Stomach, Intestine.
Expression data is available from the Allen Human Brain Atlas.
KCNH6 mutations are linked to the following conditions:
Gastrointestinal Disorders, Intestinal Motility
The study of Kcnh6 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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- KCa channels in neurodegeneration: Shah NH, et al. Nat Rev Neurosci. 2018;19(9):485-498. PMID:30046008
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