Kca1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCA1B encodes the beta1 regulatory subunit of BK channels. It modulates channel gating and trafficking. Beta1 subunits regulate smooth muscle contractility and are important for neuronal function.
KCA1B (Potassium Calcium-Activated Channel Subfamily M Beta 1) is a gene located on chromosome 5q12 that plays an important role in neurodegenerative disease. Mutations in KCA1B are associated with Neurological Disorders. The gene is catalogued as NCBI Gene ID 6130 and OMIM 608165.
The KCA1B gene encodes a protein involved in key neuronal functions. It is expressed in Brain, Heart, Muscle.
Expression data is available from the Allen Human Brain Atlas.
KCA1B mutations are linked to the following conditions:
Neurological Disorders
The study of Kca1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Potassium channels in neurons: Hille B. Ionic Channels of Excitable Membranes. 3rd ed. Sinauer Associates; 2001.
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