INPP4B (inositol polyphosphate-4-phosphatase type II) is a lipid phosphatase belonging to the same family as INPP4A. It plays important roles in phosphoinositide signaling and has been implicated in Parkinson's disease pathogenesis through endolysosomal pathway regulation.
| Attribute | Value |
|---|---|
| Gene Symbol | INPP4B |
| Full Name | Inositol Polyphosphate-4-Phosphatase Type II |
| Chromosome | 4q21.21 |
| Protein Type | Phosphatase |
| Function | Dephosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol 4-phosphate (PI4P) |
INPP4B is expressed in various brain regions including the substantia nigra:
Recent studies have identified INPP4B as a PD-relevant gene:
| Approach | Description | Status |
|---|---|---|
| Small Molecule Modulators | Develop INPP4B-targeting compounds | Preclinical |
| Target Validation | Confirm INPP4B biology in PD models | Ongoing |
| Biomarker Development | INPP4B as PD progression marker | Early research |
| Feature | INPP4A | INPP4B |
|---|---|---|
| Chromosome | 9q34.3 | 4q21.21 |
| Expression | High in brain | Broad tissue distribution |
| PD Evidence | Strong (PMID 41866087) | Emerging |
| Therapeutic Target | High priority | Investigational |