| IL7R — Interleukin-7 Receptor Alpha Chain | |
|---|---|
| Symbol | IL7R |
| Full Name | Interleukin-7 Receptor Alpha Chain |
| Chromosome | 5p13.2 |
| NCBI Gene | 3575 |
| Ensembl | ENSG00000168685 |
| OMIM | 146661 |
| UniProt | P16871 |
| Diseases | [Multiple Sclerosis](/diseases/multiple-sclerosis), [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease) |
| Expression | T cells, B cells, brain ([neurons](/entities/neurons), microglia) |
Il7R Gene Interleukin 7 Receptor Alpha Chain plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
IL7R (Interleukin-7 Receptor Alpha Chain) is a gene located on chromosome 5p13.2 that encodes the alpha chain of the interleukin-7 receptor (IL-7Rα). This receptor is essential for T cell development and survival and has been implicated in neurodegenerative diseases through its role in neuroinflammation and immune regulation[1]. Genetic variants in IL7R are associated with increased risk for multiple sclerosis and other neurological conditions[2].
The IL7R gene spans approximately 16 kb of genomic DNA on chromosome 5p13.2 and consists of 8 exons. The gene encodes a 439 amino acid type I transmembrane protein that forms the IL-7 receptor α chain. This chain pairs with the common gamma chain (γc, encoded by IL2RG) to form the functional IL-7 receptor[3].
The IL-7 receptor plays critical roles in immune system development and function:
In the central nervous system, IL-7R is expressed on:
IL7R is one of the most significant genetic risk factors for MS:
IL7R has been implicated in AD through neuroinflammation:
In PD, IL7R contributes to neuroinflammation:
IL7R variants have also been associated with:
IL7R represents a therapeutic target:
Il7R Gene Interleukin 7 Receptor Alpha Chain plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Il7R Gene Interleukin 7 Receptor Alpha Chain has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.