| IL1RAP — Interleukin-1 receptor accessory protein | |
|---|---|
| Symbol | IL1RAP |
| Full Name | Interleukin-1 receptor accessory protein |
| Chromosome | 3q28 |
| NCBI Gene | 3556 |
| Ensembl | ENSG00000124788 |
| OMIM | 602463 |
| UniProt | Q9NPH8 |
| Diseases | Alzheimer's Disease, Multiple Sclerosis |
| Expression | Brain (microglia, astrocytes), Spleen, Liver |
IL1RAP is a gene implicated in neurodegenerative diseases. This page provides comprehensive information about this gene, its functions, and its relevance to disease mechanisms.
IL1RAP is a coreceptor for interleukin-1 receptor family members, essential for IL-1 signaling. It plays a critical role in neuroinflammation, a key pathological feature of Alzheimer's disease and other neurodegenerative disorders.
The gene encodes a protein that plays important roles in normal neuronal function and survival. Understanding its normal function provides insight into how dysregulation contributes to neurodegenerative processes in diseases such as Alzheimer's disease, Parkinson's disease, and ALS.
IL1RAP encodes a protein involved in various cellular processes relevant to neuronal health. The protein localizes to specific cellular compartments and participates in signaling pathways that regulate:
IL1RAP is expressed in Brain (microglia, astrocytes), Spleen, Liver. This expression pattern suggests roles in both central nervous system function and peripheral tissues. In the brain, expression is often enriched in specific neuronal populations.
Alterations in IL1RAP expression or function have been reported in Alzheimer's disease brain tissue. Changes may contribute to amyloid processing, tau pathology, synaptic dysfunction, or neuronal loss.
IL1RAP has been implicated in Parkinson's disease pathogenesis through roles in dopaminergic neuron survival, protein aggregation, or mitochondrial dysfunction.
Depending on its specific function, IL1RAP may also play roles in other neurodegenerative conditions including ALS, Huntington's disease, and frontotemporal dementia.
Understanding the role of IL1RAP in neurodegeneration may lead to therapeutic strategies targeting: