Ikbka Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ikbka Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Alpha | |
|---|---|
| Gene Symbol | IKBKA |
| Full Name | Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Alpha |
| Chromosome | 10q24 |
| NCBI Gene ID | 1147 |
| OMIM | 600664 |
| Ensembl ID | ENSG00000115607 |
| UniProt ID | O15111 |
| Associated Diseases | Immunodeficiency, Autoimmune Disorders |
IKBKA encodes IKKα, a catalytic subunit of the IκB kinase complex. While IKKα can phosphorylate IκB, it also has distinct roles in the non-canonical NF-κB pathway and regulates cell differentiation and development.
Expressed in most tissues, including brain.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Alzheimer's Disease | Altered expression | - | Chronic NF-κB activation promotes neuroinflammation, microglial activation, and neuronal death |
| Parkinson's Disease | Altered expression | - | Contributes to neuroinflammation and dopaminergic neuron loss |
| Multiple Sclerosis | Altered expression | - | Regulates immune cell activation and demyelination |
| Various | See specific diseases | - | Role in inflammatory responses and cell survival |
Ikbka Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ikbka Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduction and Targeted Therapy. 2023. ↩︎