Ifi204 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox Gene
| gene_name = IFI204
| full_name = interferon alpha inducible protein 204
| chromosome = 1
| location = 1q23.1
| ncbi_gene_id = 3430
| omim = -
| ensembl = ENSG00000108509
| uniprot = Q12906
| aliases = IFI204, AIM2, PYHIN1
}}
IFO204 is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of IFO204 is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The IFI204 gene (also known as AIM2-like receptor or PYHIN1) encodes a member of the AIM2-like receptor (ALR) family. IFI204 contains a HIN-200 (interferon-inducible protein 200) domain that can bind DNA and a PYD (pyrin domain) for protein-protein interactions. It functions as a DNA sensor involved in innate immunity and inflammasome activation. Upon binding to cytosolic DNA, IFI204 recruits ASC and pro-caspase-1 to form an inflammasome complex.
IFI204/AIM2 is implicated in Alzheimer's disease:
In Parkinson's disease:
IFI204 is expressed in:
Expression is upregulated by type I and II interferons.
The study of Ifi204 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.