Ide Gene Insulin Degrading Enzyme is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The IDE (Insulin-Degrading Enzyme) gene encodes a ubiquitously expressed thiol metalloprotease that degrades insulin, amyloid-beta, and other peptides. IDE plays critical roles in metabolism and proteostasis, with particular relevance to Alzheimer's disease and diabetes. Located on chromosome 10q23.33, IDE has been extensively studied for its role in clearing amyloid-beta peptides and its potential as a therapeutic target for neurodegenerative diseases. [1]
This gene is involved in: [2]
IDE (Insulin-Degrading Enzyme), also known as insulysin, is a gene encoding a ubiquitously expressed thiol metalloprotease that degrades insulin, amyloid-beta, and other peptides. It plays critical roles in metabolism and proteostasis, with particular relevance to Alzheimer's disease and diabetes. The IDE gene has been extensively studied for its role in clearing amyloid-beta peptides and its potential as a therapeutic target for neurodegenerative diseases. [3]
| Property | Value | [4]
|----------|-------|
| Gene Symbol | IDE |
| Chromosomal Location | 10q23.33 |
| NCBI Gene ID | 3416 |
| Protein | Insulin-Degrading Enzyme (IDE) |
| Molecular Weight | ~110 kDa |
| Function | Peptide hydrolysis, amyloid clearance |
| Related Diseases | Alzheimer's Disease, Parkinson's Disease, Type 2 Diabetes |
IDE is a zinc-dependent metallopeptidase consisting of 1019 amino acids that performs several critical functions in cellular proteostasis:
IDE degrades a wide range of peptide substrates:
IDE exhibits unique enzymatic properties:
IDE plays a critical role in Alzheimer's disease pathogenesis:
IDE involvement in Parkinson's disease includes:
The connection between type 2 diabetes and neurodegenerative diseases:
IDE is ubiquitously expressed throughout the body:
Several IDE variants have been associated with disease risk:
Compounds that increase IDE expression or activity:
Targeting IDE's unique substrate-binding site:
Rational combinations for enhanced efficacy:
The study of Ide Gene Insulin Degrading Enzyme has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kurochkin IV, Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 1994. ↩︎
Styczynski J, et al. polymorphisms with Alzheimer's disease Association of IDE gene. Neurology. 2010. ↩︎
Vepsalainen S, et al. IDE in the brain: implications for Alzheimer's disease. J Mol Neurosci. 2014. ↩︎
Zhao L, et al. Brain insulin signaling and Alzheimer's disease. Curr Alzheimer Res. 2012. ↩︎