Hspa4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The HSPA4 gene encodes Hsp70 family member 4 (also known as APG-2 or Hsp70RY), a member of the Hsp70 family of heat shock proteins. HSPA4 is a molecular chaperone involved in protein folding, refolding, and degradation. It plays important roles in cellular stress response and has been implicated in various neurodegenerative diseases. [1]
| Property | Value | [2]
|---|---| [3]
| Gene Symbol | HSPA4 | [4]
| Full Name | Heat Shock Protein Family A (Hsp70) Member 4 |
| Chromosomal Location | 1q22 |
| NCBI Gene ID | 3309 |
| UniProt ID | Q9Y4X5 |
| Protein Class | Hsp70 Family |
HSPA4 (also known as Hsp70L1 or Apg-2) is a constitutively expressed Hsp70 family member with multiple cellular functions:
Hsp70 family members are attractive drug targets:
The study of Hspa4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4), also known as APG-2, is a member of the Hsp70 family with chaperone activity:
HSPA4 functions in:
Mayer MP, et al. Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci. 2005. ↩︎
Broadley SA, et al. Heat shock proteins in neurodegeneration. J Neurol Neurosurg Psychiatry. 2009. ↩︎
Balakrishnan K, et al. Targeting Hsp70 and Hsp40 in cancer therapy. Cancer Biol Ther. 2010. ↩︎
Jinwal UK, et al. Hsp70 ATPase inhibitors as therapeutic agents. CNS Neurol Disord Drug Targets. 2009. ↩︎