Hspa14 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
HSPA14 (Heat Shock Protein Family A (Hsp70) Member 14) is a member of the Hsp70 family of molecular chaperones. It is also known as HSP70L1 or Hsp70-like protein. HSPA14 is involved in protein folding, assembly of protein complexes, and cellular stress responses. The gene is located on chromosome 2p22.2 and encodes a protein of approximately 517 amino acids. [1]
| Property | Value | [2]
|----------|-------| [3]
| Gene Symbol | HSPA14 | [4]
| Gene Name | Heat Shock Protein Family A (Hsp70) Member 14 | [5]
| Alternative Names | HSP70L1, Hsp70L1, HSP70-14 |
| Chromosomal Location | 2p22.2 |
| NCBI Gene ID | 51282 |
| UniProt ID | Q9NSE4 |
| Ensembl ID | ENSG00000174177 |
| Protein Family | Hsp70 family |
| Molecular Weight | ~56 kDa |
| Amino Acids | ~517 |
HSPA14 contains the conserved Hsp70 domain structure:
HSPA14 functions as a molecular chaperone:
HSPA14 in AD:
In PD:
In ALS:
| Strategy | Approach | Status |
|---|---|---|
| Hsp70 activators | Enhance chaperone activity | Preclinical |
| Co-chaperone modulators | Alter Hsp70 complex | Research |
| Combination therapy | With Hsp90 inhibitors | Research |
The study of Hspa14 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.