Hsp90B1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Hsp90B1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | HSP90B1 |
|---|---|
| Gene Name | Heat Shock Protein 90 Beta Family Member 1 |
| Chromosome | 15q26.3 |
| NCBI Gene ID | 27197 |
| OMIM | 611719 |
| UniProt | P14625 |
| Associated Diseases | Neurodegeneration |
GRP94; ER chaperone; protein folding and quality control
The HSP90B1 gene is implicated in neurodegenerative diseases including:
HSP90B1 is expressed in the brain, with highest expression in neurons.
Hsp90B1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Hsp90B1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Zhang L, Li W, Wang Y, et al. HSP90B1 (Heat Shock Protein 90 Beta Family Member 1) in protein folding and neuroprotection. Mol Neurobiol. 2019;56(6): 4218-4231. PubMed
Fujita R, Sato K. The role of GRP94 (HSP90B1) in ER homeostasis and neurodegeneration. J Neurochem. 2020;155(1): 23-37. PubMed
Blatt NB, Boal K, Smith J, et al. HSP90B1 in mitochondrial protein import and neuronal survival. Cell Mol Neurobiol. 2018;38(1): 87-100. PubMed
Takeda M, Nakamura K, et al. Molecular chaperones in Parkinson's disease: Hsp90B1 and alpha-synuclein. Neurobiol Dis. 2019;132: 104527. PubMed
Tanaka K, Yamaguchi A. Targeting HSP90B1 for Alzheimer's disease therapy. Adv Exp Med Biol. 2020;1195: 67-79. PubMed
Hayashi R, Kawaguchi A. GRP94 in calcium homeostasis and ER stress response. Cell Calcium. 2021;95: 102288. PubMed
Yoshida K, Fujita H. Hsp90 inhibitors in neurodegenerative diseases: clinical potential. Expert Opin Ther Targets. 2022;26(1): 55-68. PubMed
Abe K, Saito H. HSP90B1 mutations and hereditary neuropathy. Neurology. 2020;94(15): e1589-e1600. PubMed