Hspb1 — Heat Shock Protein Family B Member 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this gene. See the content below for detailed information.
| Symbol |
HSPB1 |
| Full Name |
Heat Shock Protein Family B Member 1 (Hsp27) |
| Chromosome |
7q11.23 |
| NCBI Gene |
3315 |
| Ensembl |
ENSG00000178462 |
| OMIM |
604533 |
| UniProt |
P04792 |
| Diseases |
Charcot-Marie-Tooth Disease, ALS, Neuropathy |
| Expression |
Ubiquitous, High in brain, Spinal cord, Peripheral nerves |
HSP27 (HspB1) is a small heat shock protein with anti-apoptotic and neuroprotective properties. It helps protect neurons from oxidative stress and protein aggregation, and is implicated in various peripheral neuropathies.
The HSPB1 gene encodes Heat Shock Protein 27, a small heat shock protein that functions as a molecular chaperone. Hsp27 protects cells from various stresses including heat shock, oxidative stress, and apoptotic stimuli. It inhibits caspase activation, stabilizes the cytoskeleton, and helps refold damaged proteins.
Charcot-Marie-Tooth Disease, ALS, Neuropathy — Mutations in HSPB1 are associated with Charcot-Marie-Tooth disease type 2 (CMT2) and other peripheral neuropathies. Hsp27 has been studied as a potential therapeutic target in ALS due to its neuroprotective properties.
HSPB1 is ubiquitously expressed with high levels in brain, spinal cord, and peripheral nerves. Its expression is induced by cellular stress.
The study of Hspb1 — Heat Shock Protein Family B Member 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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- D Steele, J Twyman, P Sharoff. The role of small heat shock proteins in neurodegeneration. Adv Exp Med Biol. 2015;822:93-103. DOI
- Voss OH, Batra S, Kolattukudy SJ, Gonzalez-Mejia ME, Buttle E, Israel A. Binding of Hsp27 to LRP1 modulates Notch1 signaling and neuronal survival. Cell Signal. 2015;27(7):1339-1347. DOI
- Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 2002;295(5556):865-868. DOI