.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px;
font-size: 0.9em;
}
.infobox .infobox-gene .gene-symbol {
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}
.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}
.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}
.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}
.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}
.infobox .infobox-gene td.value {
width: 60%;
}
.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}
.infobox .infobox-gene a:hover {
text-decoration: underline;
}
| Symbol | HRH3 |
| Full Name | Histamine Receptor H3 |
| Chromosome | 20q13.33 |
| NCBI Gene | 11255 |
| OMIM | 607340 |
| Ensembl | ENSG00000101180 |
| UniProt | Q9Y5N1 |
| Associated Diseases | Narcolepsy, cognition, addiction |
HRH3 (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The HRH3 gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The HRH3 subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in HRH3 are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
HRH3 encodes the histamine H3 receptor, which acts as an autoreceptor for histamine and modulates histamine release in the brain. It is widely expressed in the central nervous system and is involved in sleep-wake cycles, cognition, and energy homeostasis.
HRH3 encodes the H3 histamine receptor. Functions as an autoreceptor and regulates histamine release. Important for sleep-wake cycle and cognition.
High expression in cortex, hippocampus, and hypothalamus.