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| Symbol | HRH2 |
| Full Name | Histamine Receptor H2 |
| Chromosome | 5q35.2 |
| NCBI Gene | 3374 |
| OMIM | 142703 |
| Ensembl | ENSG00000100349 |
| UniProt | P25021 |
| Associated Diseases | Gastric acid secretion, cognition |
HRH2 (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The HRH2 gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The HRH2 subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in HRH2 are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
HRH2 encodes the histamine H2 receptor that stimulates gastric acid secretion and modulates immune responses. In the brain, it is involved in circadian rhythm regulation and cognitive functions.
HRH2 encodes the H2 histamine receptor. Couples to Gs and stimulates cAMP. Important for gastric acid secretion and memory.
Expressed in stomach and brain.