Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Homer2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Homer Scaffold Protein 2 | |
|---|---|
| Gene Symbol | HOMER2 |
| Full Name | Homer Scaffold Protein 2 |
| Chromosome | 15q24.3 |
| NCBI Gene ID | 9455 |
| OMIM | 604869 |
| Ensembl ID | ENSG00000124827 |
| UniProt ID | Q9NSC5 |
| Associated Diseases | Alzheimer's Disease, Schizophrenia, Autism Spectrum Disorders, Epilepsy |
HOMER2 encodes Homer 2, a scaffolding protein that organizes postsynaptic density structures and regulates synaptic signaling. Homer proteins bind to group I metabotropic glutamate receptors (mGluR1/5), Shank proteins, and other synaptic components. Homer 2 is particularly important for mGluR5 signaling, calcium homeostasis, and synaptic plasticity. Reduced Homer 2 expression has been reported in Alzheimer's disease brains, contributing to disrupted glutamatergic signaling and synaptic dysfunction.
High expression in brain, particularly in the cerebral cortex, hippocampus, and cerebellum. Expressed in neurons at postsynaptic densities.
| Disease | Mechanism |
|---|---|
| Alzheimer's Disease | |
| Schizophrenia | |
| Autism Spectrum Disorders | |
| Epilepsy |
| Partner | Interaction Type | Pathway |
|---|
No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.
Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Homer2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.