Hla A — Major Histocompatibility Complex Class I A is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| HLA-A | |
|---|---|
| Major Histocompatibility Complex Class I A | |
| Gene Symbol | HLA-A |
| Full Name | Major Histocompatibility Complex Class I A |
| Chromosome | 6p21.3 |
| NCBI Gene ID | 3105 |
| Ensembl ID | ENSG00000206503 |
| OMIM | 142800 |
| UniProt ID | P01890 |
| Associated Diseases | Multiple Sclerosis, Parkinson's Disease, Alzheimer's Disease, Narcolepsy |
| Expression | All nucleated cells, Immune cells, Brain (microglia) |
HLA-A (Major Histocompatibility Complex Class I A) is a gene located on chromosome 6p21.3 that encodes the HLA class I heavy chain alpha subunit. HLA-A is a cell surface antigen that presents endogenous peptides to CD8+ cytotoxic T-cells, playing a central role in the immune recognition of infected or transformed cells.
HLA-A presents peptide antigens to T-cells:
The study of Hla A — Major Histocompatibility Complex Class I A has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.