Hgsnat Heparan Alpha Glucosaminide N Acetyltransferase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Heparan-Alpha-Glucosaminide N-Acetyltransferase | |
|---|---|
| Gene Symbol | HGSNAT |
| Full Name | Heparan-Alpha-Glucosaminide N-Acetyltransferase |
| Chromosome | 8p11.21 |
| NCBI Gene ID | 63805 |
| OMIM | 610539 |
| Ensembl ID | ENSG00000145192 |
| UniProt ID | Q9Y5S9 |
| Associated Diseases | Mucopolysaccharidosis IIIC (Sanfilippo C) |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
Heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the acetylation of the terminal alpha-glucosamine residue in heparan sulfate. This is a critical step in the lysosomal degradation of heparan sulfate[^1].
HGSNAT performs functions:
HGSNAT mutations cause MPS IIIC:
HGSNAT is expressed in:
The study of Hgsnat Heparan Alpha Glucosaminide N Acetyltransferase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.