Herpud1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Herpud1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein 1) is a critical component of the ER quality control system. It plays a key role in ER-associated degradation (ERAD) and has been implicated in various neurodegenerative diseases where ER stress is a prominent feature.
| Property | Value |
|---|---|
| Gene Symbol | HERPUD1 |
| Full Name | Homocysteine-responsive ER-resident ubiquitin-like domain protein 1 |
| Chromosomal Location | 16q13 |
| NCBI Gene ID | 9709 |
| OMIM | 607340 |
| Ensembl ID | ENSG00000128604 |
| UniProt | Q9Y5X5 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Hereditary Spastic Paraplegia |
HERPUD1 is a multifunctional ER protein with critical roles in cellular homeostasis:
HERPUD1 is expressed in:
Title: HERPUD1 protects against ER stress-induced cell death
Authors: Sarras H, et al.
Journal: Cell Death & Differentiation
Year: 2010
[DOI:10.1038/cdd.2010.39](https://doi.org/10.1038/cdd.2010.39)
Title: ER stress in Alzheimer's disease: the role of HERPUD1
Authors: Hoozemans JJ, et al.
Journal: Journal of Alzheimer's Disease
Year: 2012
[DOI:10.3233/JAD-2012-120229](https://doi.org/10.3233/JAD-2012-120229)
Herpud1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Herpud1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.