Hdac7 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
HDAC7 (Histone Deacetylase 7) is a gene located on chromosome 5q31 that encodes a class IIa histone deacetylase involved in epigenetic regulation, transcriptional repression, and development.
| Property | Value |
|----------|-------|
| **Gene Symbol** | HDAC7 |
| **Full Name** | Histone Deacetylase 7 |
| **Chromosomal Location** | 5q31.3 |
| **NCBI Gene ID** | 51564 |
| **OMIM** | 606543 |
| **Ensembl ID** | ENSG00000161296 |
| **UniProt ID** | Q8WUI4 |
| **Associated Diseases** | Neurodegeneration, Cancer, Cardiovascular Disease |
HDAC7 is a Class IIa histone deacetylase:
- Epigenetic Regulation: Deacetylates histones, repressing transcription
- Transcriptional Repression: Represses gene expression via chromatin modification
- Development: Critical for embryonic development
- Cell Differentiation: Regulates differentiation programs
- Immune Function: Modulates immune cell development
HDAC7 is implicated in neurodegenerative diseases:
- Mechanism: Dysregulated histone acetylation
HDAC7 is dysregulated in various cancers:
The HDAC7 protein contains:
- N-terminal regulatory domain: Contains binding sites for transcription factors
- C-terminal catalytic domain: Histone deacetylase activity
- Nuclear localization signal (NLS): Nuclear import
HDAC7 is expressed in:
- Brain
- Heart, muscle
- Immune cells
- HDAC Inhibitors: Selective HDAC7 modulators
- Epigenetic Therapy: Restore proper histone acetylation
The study of Hdac7 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.