Gstp1 — Glutathione S Transferase Pi 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Official Symbol: GSTP1 [1]
Official Full Name: Glutathione S-Transferase Pi 1 [2]
Gene Type: Protein Coding [3]
Location: Chromosome 11q13.2 [4]
NCBI Gene ID: 2950 [5]
Ensembl ID: ENSG00000084207 [6]
UniProt ID: P09211 [7]
Glutathione S-Transferase Pi 1 (GSTP1) is a member of the GST family of enzymes that catalyze the conjugation of glutathione (GSH) to various electrophilic compounds. This enzyme plays important roles in detoxification, antioxidant defense, and regulation of cell signaling pathways. In the brain, GSTP1 is expressed in neurons and glia and contributes to neuroprotection against oxidative stress and xenobiotics.
The study of Gstp1 — Glutathione S Transferase Pi 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Clements J et al. GSTP1 in the brain (2010). 2010. ↩︎
Johnson JD et al. GSTP1 and AD (2003). 2003. ↩︎
Saadat M et al. GSTP1 polymorphisms in PD (2006). 2006. ↩︎
van der Westhuizen FH et al. GSTP1 and neurodegeneration (2005). 2005. ↩︎
Hayes JD et al. Glutathione transferases (2005). 2005. ↩︎
Aldred S et al. GSTP1 in aging brain (2011). 2011. ↩︎
Tew KD et al. GSTP1 as therapeutic target (2011). 2011. ↩︎