Gsr — Glutathione Reductase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Official Symbol: GSR [1]
Official Full Name: Glutathione Reductase [2]
Gene Type: Protein Coding [3]
Location: Chromosome 8p12 [4]
NCBI Gene ID: 2935 [5]
Ensembl ID: ENSG00000100647 [6]
UniProt ID: P16455 [7]
Glutathione Reductase (GSR) is a flavoprotein enzyme that maintains the reduced state of glutathione (GSH) in cells. This enzyme is essential for cellular redox homeostasis, converting oxidized glutathione (GSSG) back to its reduced form (GSH) using NADPH as an electron donor. GSR is crucial for protecting cells, including neurons, from oxidative stress, which is a central contributor to neurodegenerative diseases.
The study of Gsr — Glutathione Reductase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Smeyne M et al. GSR and Parkinson's disease (2007). 2007. ↩︎
Lovell MA et al. Oxidative stress in AD brain (2000). 2000. ↩︎
Bains JS et al. GSR and ALS (2009). 2009. ↩︎
Rai V et al. GSR in stroke (2018). 2018. ↩︎
Kirsch J et al. GSR and oxidative stress (2011). 2011. ↩︎
Balijepalli S et al. GSR polymorphisms in neurodegeneration (2019). 2019. ↩︎
Zhang J et al. Targeting GSR in neurodegeneration (2022). 2022. ↩︎