Grin2D Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| GRIN2D | |
|---|---|
| Gene Symbol | GRIN2D |
| Full Name | Glutamate Ionotropic Receptor NMDA Type Subunit 2D |
| Chromosomal Location | 19q13.1 |
| NCBI Gene ID | 2905 |
| OMIM ID | 602717 |
| Ensembl ID | ENSG00000105464 |
| UniProt ID | Q9NSY9 |
| Encoded Protein | GluN2D |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Huntington's Disease |
The GRIN2D gene encodes GluN2D, a protein involved in glutamate ionotropic receptor nmda type subunit 2d.
Glutamate Ionotropic Receptor NMDA Type Subunit 2D plays critical roles in cellular processes including:
GRIN2D mutations or dysregulation are associated with alzheimer's disease, contributing to disease pathogenesis through various mechanisms including protein aggregation, signaling dysregulation, and cellular stress responses.
GRIN2D is expressed in multiple brain regions with highest expression in:
The study of Grin2D Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.