Gnptg Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Gnptg Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GNPTG (N-acetylglucosamine-1-phosphate transferase gamma subunit) encodes the gamma subunit of the enzyme that initiates lysosomal enzyme targeting. Together with the alpha and beta subunits encoded by GNPTAB, GNPTG forms the phosphotransferase complex essential for proper lysosomal function.
| Property | Value |
|---|---|
| Gene Symbol | GNPTG |
| Full Name | N-acetylglucosamine-1-phosphate transferase gamma subunit |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 345611 |
| OMIM — | |
| Ensembl ID | ENSG00000196937 |
| UniProt | Q9NRR5 |
| Associated Diseases | Mucolipidosis III, Parkinson's Disease |
GNPTG is a crucial component of the lysosomal enzyme targeting system:
GNPTAB is expressed in:
Title: Structure and function of the GNPTAB and GNPTG enzymes
Authors: Kornfeld R, et al.
Journal: Journal of Inherited Metabolic Disease
Year: 2010
[DOI:10.1007/s10545-010-9051-4](https://doi.org/10.1007/s10545-010-9051-4)
Gnptg Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Gnptg Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.