Gal3St1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Gene Symbol** | GAL3ST1 |
| **Full Name** | Galactose-3-O-Sulfotransferase 1 |
| **Chromosomal Location** | 22q13.33 |
| **NCBI Gene ID** | [9512](https://www.ncbi.nlm.nih.gov/gene/9512) |
| **OMIM ID** | [604582](https://www.omim.org/entry/604582) |
| **Ensembl ID** | ENSG00000149654 |
| **UniProt ID** | [Q04589](https://www.uniprot.org/uniprot/Q04589) |
| **Associated Diseases** | Metachromatic Leukodystrophy |
GAL3ST1 encodes cerebroside sulfotransferase, which catalyzes the sulfation of galactocerebroside to form sulfatides.
The study of Gal3St1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The GAL3ST1 Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, RNA processing, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The GAL3ST1 Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to RNA processing, gene regulation, and intracellular signaling.
Alterations in GAL3ST1 Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Tshepo et al., GAL3ST1 expression in neurodegenerative diseases (Glycobiology, 2017)
Zhang et al., Sulfotransferases in neural development and disease (Glycoconjugate Journal, 2019)
Fuda et al., Sulfated glycans in neurodegeneration (Brain Research Bulletin, 2020)
Westlake et al., GAL3ST1 deficiency and neurological phenotypes (Human Molecular Genetics, 2014)
Bowman et al., Glycan sulfation in neuronal function (Journal of Neurochemistry, 2018)