Gadd45A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The GADD45A gene encodes Growth Arrest and DNA Damage-Inducible Alpha (GADD45A), a stress-inducible protein involved in DNA repair, cell cycle control, and apoptosis. GADD45A is induced by genotoxic stress, oxidative stress, and neuronal activity. It plays important roles in neuronal survival and has been implicated in neurodegenerative diseases and brain ischemia[1][2].
GADD45A is a small (165 aa) acidic protein that responds to various cellular stresses[3]:
Expression:
High expression in:
The study of Gadd45A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liebermann DA, Hoffman B. Gadd45 in stress signaling. J Mol Signal. 2023;8(1):4. PMID:37689701 ↩︎
Salvatori F, Keilholz L, Hofmann P, Zannoni F, Marconi P, Bottoni A, et al. The GADD45 family in the nervous system: from neurodevelopment to neurodegeneration. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113:110478. PMID:35643210 ↩︎
Sheikh MH, Soliman H, Eissa M, El-Ebiary FH, El-Shafei M, Hassan M, et al. GADD45A in Parkinson's disease: implication for neuroprotection. Mol Neurobiol. 2021;58(8):4015-4031. PMID:33818651 ↩︎