Fzd4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| FZD4 Gene | |
|---|---|
| Frizzled Class Receptor 4 | |
| Symbol | FZD4 |
| Full Name | Frizzled Class Receptor 4 |
| Chromosome | 11q14.2 |
| NCBI Gene ID | 2762 |
| Ensembl ID | ENSG00000174804 |
| OMIM ID | 604579 |
| UniProt ID | Q9ULV1 |
| Associated Diseases | Familial Exudative Vitreoretinopathy, Alzheimer's Disease, Stroke |
FZD4 (Frizzled Class Receptor 4) is a seven-transmembrane receptor that primarily activates canonical Wnt/β-catenin signaling. It plays essential roles in vascular development, neural tube formation, and blood-brain barrier (BBB) maintenance. FZD4 is expressed in endothelial cells, neural progenitors, and mature neurons.
FZD4 is a primary receptor for Wnt/β-catenin pathway:
FZD4 critically regulates BBB formation and maintenance:
FZD4 in nervous system development:
FZD4 mutations cause FEVR:
FZD4 contributes to AD pathogenesis:
FZD4 protective effects:
FZD4 is expressed in:
FZD4 interacts with:
FZD4-based therapies for:
The study of Fzd4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.