Flot1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Flot1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
FLOT1 (Flotillin 1) is a lipid raft-associated protein involved in cellular membrane organization, signal transduction, and neuroinflammation. It plays emerging roles in neurodegenerative disease pathogenesis. [2]
| Property | Value |
|---|---|
| Gene Symbol | FLOT1 |
| Full Name | Flotillin 1 |
| Chromosomal Location | 6p21.3 |
| NCBI Gene ID | 10211 |
| OMIM ID | 606823 |
| Ensembl ID | ENSG00000231768 |
| UniProt ID | O75955 |
FLOT1 is a ~47 kDa integral membrane protein:
FLOT1 forms hetero-oligomeric complexes in lipid rafts.
FLOT1 performs essential cellular functions:
| Brain Region | Expression Level |
|---|---|
| Hippocampus | Moderate-High |
| Cerebral Cortex | Moderate-High |
| Cerebellum | Moderate |
| Basal Ganglia | Moderate |
| Brain Stem | Low-Moderate |
FLOT1 is expressed in:
Flot1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Flot1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.