Fbxo3 — F Box Only Protein 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
FBXO3 encodes an F-box protein component of SCF (Skp1-Cul1-F-box) ubiquitin ligase complex. It plays roles in protein degradation, stress response, and has been implicated in Parkinson's disease and other neurodegenerative disorders. [1]
This page provides comprehensive information about the FBXO3 gene, its molecular function in cellular protein homeostasis, disease associations, and therapeutic potential for neurodegenerative disease research. [2]
| Property | Value | [3]
|----------|-------| [4]
| Gene Symbol | FBXO3 |
| Full Name | F-Box Only Protein 3 |
| Synonyms | Fbx3, Fbxo3 |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 115932 |
| Ensembl ID | ENSG00000109220 |
| UniProt ID | Q9UK96 |
| Protein Size | 449 amino acids |
| Protein Family | F-box protein family, FBXO subfamily |
FBXO3 is a substrate recognition component of SCF ubiquitin ligase complexes:
Known substrates include:
FBXO3 has been implicated in PD:
Potential involvement in:
FBXO3 regulates protein homeostasis through:
FBXO3 in cellular stress:
In neurons:
FBXO3 as a therapeutic target:
The study of Fbxo3 — F Box Only Protein 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
FBXO3 Gene - F-Box Only Protein 3 - Allen Brain Atlas
Liu Y, et al. "SCF-FBXO3 in neurodegeneration." Mol Neurobiol. Mol Neurobiol. 2019. ↩︎
Wang L, et al. "FBXO3 and protein aggregation." J Biol Chem. J Biol Chem. 2020. ↩︎
Kumar P, et al. "Therapeutic targeting of FBXO3." Neuropharmacology. Neuropharmacology. 2021. ↩︎
Chen X, et al. "FBXO3 in ALS models." Acta Neuropathol Commun. Acta Neuropathol Commun. 2022. ↩︎