FAS (Fas cell surface death receptor) is a member of the TNF receptor superfamily that plays a critical role in the extrinsic apoptosis pathway. It is widely expressed in the nervous system and contributes to neuronal death in various neurodegenerative diseases.
FAS (also known as CD95 or APO-1) is a cell surface receptor that triggers apoptosis upon binding with its ligand FASLG. It is a type I transmembrane protein containing death domains that initiate caspase-8 activation. [1]
| Fas Cell Surface Death Receptor | |
|---|---|
| Gene Symbol | FAS |
| Full Name | Fas Cell Surface Death Receptor |
| Chromosome | 10q23.31 |
| NCBI Gene ID | [3558](https://www.ncbi.nlm.nih.gov/gene/3558) |
| OMIM | [134637](https://www.omim.org/entry/134637) |
| Ensembl ID | [ENSG00000026103](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000026103) |
| UniProt ID | [P01375](https://www.uniprot.org/uniprot/P01375) |
FAS mediates the extrinsic apoptosis pathway:
FAS contributes to AD pathogenesis:
In PD, FAS mediates dopaminergic neuron death:
FAS is implicated in motor neuron disease:
FAS contributes to acute brain injury:
FAS/FASL pathway inhibitors are investigated:
| Agent | Mechanism | Status | Disease |
|---|---|---|---|
| FAS siRNA | Gene silencing | Research | Stroke |
| Anti-FASL antibodies | Block ligand | Preclinical | Neuroprotection |
| FADD dominant negative | Block DISC | Research | TBI |
| Disease | Role | Evidence |
|---|---|---|
| Alzheimer's Disease | Neuronal apoptosis | Elevated FAS in AD brain |
| Parkinson's Disease | Dopaminergic death | FAS activation in PD models |
| ALS | Motor neuron death | FAS-mediated apoptosis |
| Stroke | Ischemic injury | FAS knockout protective |
FAS is expressed in brain tissue: