Fance Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Fanconi Anemia Group E | |
|---|---|
| Gene Symbol | FANCE |
| Full Name | Fanconi Anemia Group E |
| Chromosome | 6p21.31 |
| NCBI Gene ID | 2178 |
| OMIM | 604391 |
| Ensembl ID | ENSG00000112039 |
| UniProt ID | Q96GY5 |
| Associated Diseases | Fanconi Anemia |
FANCE encodes a protein that bridges the FA core complex with FANCD2, playing a crucial role in the monoubiquitination of FANCD2 essential for DNA interstrand crosslink repair.
FANCE serves as a molecular adaptor linking the FA core complex to FANCD2.
Key functions include:
FANCE is expressed ubiquitously:
The study of Fance Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
FANCE is involved in the Fanconi anemia DNA repair pathway.