Esr2 — Estrogen Receptor Beta is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Official Symbol: ESR2 [1]
Official Full Name: Estrogen Receptor 2 [2]
Gene Type: Protein Coding [3]
Location: Chromosome 14q23.2 [4]
NCBI Gene ID: 2113 [5]
Ensembl ID: ENSG00000140009 [6]
UniProt ID: Q92731 [7]
Estrogen Receptor Beta (ERβ), encoded by the ESR2 gene, is a member of the nuclear receptor superfamily that mediates estrogen signaling in various tissues, including the brain. While sharing structural homology with ESR1 (ERα), ERβ exhibits distinct expression patterns, ligand binding properties, and target gene regulation. ERβ is particularly abundant in brain regions associated with cognition and mood, and it plays important roles in neuroprotection, anti-inflammatory responses, and maintaining neuronal health.
The study of Esr2 — Estrogen Receptor Beta has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Chakraborty M et al. ERβ and neurodegenerative disease (2020). 2020. ↩︎
Zhao L et al. Estrogen receptor beta in Alzheimer's disease (2019). 2019. ↩︎
Kumar S et al. ERβ agonists for Parkinson's disease (2021). 2021. ↩︎
Christensen A et al. ERβ expression in the human brain (2019). 2019. ↩︎
Mitterling KL et al. Cellular and subcellular localization of ERβ (2010). 2010. ↩︎
Sanchez AM et al. ERβ and mitochondrial function (2022). 2022. ↩︎
Zhao L et al. Estrogen receptor beta and neuroinflammation (2021). 2021. ↩︎