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| Symbol | EPHB3 |
| Full Name | Eph Receptor B3 |
| Chromosome | 3q27.1 |
| NCBI Gene | 2049 |
| OMIM | 601067 |
| Ensembl | ENSG00000149932 |
| UniProt | P54753 |
| Associated Diseases | Colorectal cancer (neural crest involvement) |
EPHB3 (Eph Receptor B3) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-B ligands, EPHB3 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHB3 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease.
EPHB3 regulates cell migration and tissue boundary formation. In the nervous system, it participates in neural crest cell migration and axon guidance.
Expressed in developing brain and neural crest derivatives.