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| Symbol | EPHA5 |
| Full Name | Eph Receptor A5 |
| Chromosome | 5q21 |
| NCBI Gene | 1974 |
| OMIM | 600004 |
| Ensembl | ENSG00000142347 |
| UniProt | P35909 |
| Associated Diseases | Neurodevelopmental disorders |
EPHA5 (Eph Receptor A5) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-A ligands, EPHA5 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHA5 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease.
EPHA5 is an Eph receptor that participates in neural circuit formation. It regulates axonal targeting and synaptic plasticity in the visual system and hippocampus.
Expressed in cortex, hippocampus, and olfactory bulb.