.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px;
font-size: 0.9em;
}
.infobox .infobox-gene .gene-symbol {
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}
.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}
.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}
.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}
.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}
.infobox .infobox-gene td.value {
width: 60%;
}
.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}
.infobox .infobox-gene a:hover {
text-decoration: underline;
}
| Symbol | EPHA4 |
| Full Name | Eph Receptor A4 |
| Chromosome | 2q36.1 |
| NCBI Gene | 1973 |
| OMIM | 602081 |
| Ensembl | ENSG00000049286 |
| UniProt | P54764 |
| Associated Diseases | Alzheimer's disease, ALS, stroke |
EPHA4 (Eph Receptor A4) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-A ligands, EPHA4 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHA4 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease.
EPHA4 is an Eph receptor that regulates synaptic plasticity, NMJ formation, and axon guidance. It mediates excitatory synaptic transmission and is implicated in neurodegeneration and recovery from stroke.
High expression in hippocampus, cortex, and spinal cord.