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| Symbol | EPHA3 |
| Full Name | Eph Receptor A3 |
| Chromosome | 3p11.2 |
| NCBI Gene | 1972 |
| OMIM | 602335 |
| Ensembl | ENSG00000156172 |
| UniProt | P29320 |
| Associated Diseases | Brain development disorders |
EPHA3 (Eph Receptor A3) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-A ligands, EPHA3 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHA3 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease.
EPHA3 is an Eph receptor that regulates neuronal migration, axon guidance, and synaptic function. It plays roles in hippocampal development and cognitive function.
Expressed in developing and adult brain.