Eno1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
ENO1 (Enolase 1) encodes the alpha-enolase enzyme, a key glycolytic enzyme also known asENO1. Beyond its metabolic function, alpha-enolase has been implicated in various neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, where it serves as an autoantigen and stress protein. The gene is located on chromosome 1p36.23 and encodes a 433-amino acid protein.
| Attribute | Value |
|---|---|
| Symbol | ENO1 |
| Full Name | Enolase 1 (Alpha-enolase) |
| Chromosomal Location | 1p36.23 |
| NCBI Gene ID | 2023 |
| OMIM | 172430 |
| Ensembl ID | ENSG00000169064 |
| UniProt ID P06733 |
Alpha-enolase is a 433-amino acid protein (approximately 47 kDa) that forms homodimers and heterodimers with other enolase isoforms:
Alpha-enolase catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PEP), the second-to-last step of glycolysis:
2-Phosphoglycerate + Mg2+ → Phosphoenolpyruvate + H2O + Mg2+
The study of Eno1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.