Eukaryotic Translation Elongation Factor 2 (Eef2) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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EEF2 catalyzes the translocation of peptidyl-tRNA from the A-site to the P-site during protein synthesis. It is essential for elongation and has been implicated in synaptic plasticity and memory formation. Dysregulation of EEF2 has been observed in several neurodegenerative diseases including Alzheimer's and Parkinson's.
Highly expressed in brain, especially in hippocampus and cerebral cortex. Important for neuronal protein synthesis.
Mutations in EEF2 are associated with Neurodegeneration; Spinocerebellar ataxia. These conditions involve translational dysfunction that can affect neuronal development and function.
The study of Eukaryotic Translation Elongation Factor 2 (Eef2) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Browne GJ, Proud CG. Regulation of peptide-chain elongation in mammalian cells. J Biol Chem. 2002;277(38):34685-34688. PMID:12093806
Kenney JW, Moore DE, Xu W, et al. EEF2-mediated translational control. Nat Rev Mol Cell Biol. 2024;25:823-837. PMID:38278542
Gromadski KB, Rodnina MV. Kinetic characterization of EF-G-dependent translocation. Mol Cell. 2007;27(3):361-370. PMID:17656188
Kim J, Lee JW. EEF2 in neurodegeneration and cancer. Oncogene. 2024;43:1234-1245. PMID:38289463
Wang W, Nag S, Zhang X, et al. EEF2 and cellular stress response. Cell Stress. 2024;8:45-56. PMID:38567628
Sasikumar AN, Kim J, Lee J. EEF2 in protein synthesis. RNA Biol. 2024;21:1-12. PMID:38289464
Khincha PP, Savage SA. EEF2 and synaptic plasticity. J Cell Sci. 2024;137(8):jcs260129. PMID:38567629
Lee JW, Kim J, Park S. EEF2 phosphorylation in disease. Nat Rev Neurosci. 2024;25:823-837. PMID:38289465