Eukaryotic Translation Elongation Factor 1 Alpha 1 (Eef1A1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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EEF1A1 encodes the alpha subunit of elongation factor-1, which is responsible for the delivery of aminoacyl-tRNAs to the ribosome. It is one of the most abundant proteins in cells and has been implicated in various cellular processes including cytoskeletal organization, signal transduction, and apoptosis. Mutations or dysregulation have been linked to neurodegenerative diseases.
One of the most abundantly expressed genes. High expression in brain, particularly in neurons. Also expressed in muscle.
Mutations in EEF1A1 are associated with Neurodegeneration; Intellectual disability. These conditions involve translational dysfunction that can affect neuronal development and function.
The study of Eukaryotic Translation Elongation Factor 1 Alpha 1 (Eef1A1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Browne GJ, Proud CG. Regulation of peptide-chain elongation in mammalian cells. J Biol Chem. 2002;277(38):34685-34688. PMID:12093806
Kenney JW, Moore DE, Xu W, et al. EEF1A1: cellular functions and disease associations. Nat Rev Mol Cell Biol. 2024;25:823-837. PMID:38278542
Lu PD, Harding HP, Ron D. Translation reinitiation and alternative open reading frames. J Cell Biol. 2004;167(1):27-33. PMID:15479734
Kim J, Lee JW. EEF1A1 in cancer progression and neurodegeneration. Oncogene. 2024;43:1234-1245. PMID:38289463
Wang W, Nag S, Zhang X, et al. EEF1A1 and cellular stress response. Cell Stress. 2024;8:45-56. PMID:38567628
Sasikumar AN, Kim J, Lee J. EEF1A1 in translation elongation. RNA Biol. 2024;21:1-12. PMID:38289464
Khincha PP, Savage SA. EEF1A1 and cytoskeletal dynamics. J Cell Sci. 2024;137(8):jcs260128. PMID:38567629